The Hotel Siglo 21 is located in the north of the city of Mérida, a few metres from the Siglo XXI convention centre and less than 1 km from the Mundo Maya Museum. Due to its strategic location on one of the city's main avenues, the hotel is surrounded by squares, restaurants, business areas, among others; the exit to Puerto Progreso is a couple of minutes away and Manuel Crescencio Rejón International Airport is 12 km away.